Furthermore, how the metabolic environment of the mother is conveyed to the fetus remains unclear. However, the role of PA in pregnancy in altering/affecting maternal oxidative stress is not clear. PA boosts anti-oxidative capacity and ameliorates immuno-metabolic health outside of pregnancy. Increasing and maintaining physical activity and reducing sedentary behavior could control gestational weight gain, and consequently obesity and dyslipidemia. The American College of Obstetrics and Gynecologists (ACOG) recommends all women without contraindications to participate in at least 150 min of moderate PA per week. There is growing evidence that physical activity (PA) during pregnancy contributes positively to pregnancy and birth outcomes and reduces the risk of obstetric complications. Healthy lifestyle behaviors are essential in the prevention of obesity and other chronic conditions, and may also mitigate the negative consequences of obesity on maternal oxidative stress and HDL function during pregnancy. We speculate that increasing MVPA of overweight/obese women during pregnancy attenuates the oxidative stress state in the new-born. ST <20 weeks was also positively associated with inhibition of oxidation in cord blood. MVPA at 35–37 weeks correlated with higher AOPP, as well as higher anti-oxidative capacity. In contrast, MVPA at <20 weeks and 24–28 weeks of gestation were positively associated with anti-oxidative capacity, as well as PON-1 activity of HDL in cord blood. Linear regression models showed no associations of MVPA and ST with outcomes in maternal blood. This study aimed to assess the association of longitudinally and objectively measured MVPA and ST in 122 overweight/obese women (BMI ≥ 29 kg/m 2) with maternal and cord blood markers of oxidative stress measured by advanced oxidation protein products (AOPP), anti-oxidative capacity, as well as high-density lipoproteins (HDL) related paraoxonase-1 (PON-1) activity and cholesterol efflux. However, the effects of MVPA and ST on anti-oxidative and anti-atherogenic markers in pregnancy have not been studied to date. Promoting moderate to vigorous physical activity (MVPA) and decreasing sedentary time (ST) could have a positive impact on weight and obesity management, and therefore adiposity-induced oxidative stress, inflammation, and atherogenesis. Obesity is one of the most common health issues in pregnancy with short and long-term consequences for both mother and her offspring.
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